The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver

Calorie restriction (CR) is the most efficacious treatment to delay the onset of age-related changes such as mitochondrial dysfunction. However, the sensitivity of mitochondrial markers to CR and the age-related boundaries of CR efficacy are not fully elucidated. We used liver samples from ad libitum-fed (AL) rats divided in: 18-month-old (AL-18), 28-month-old (AL-28), and 32-month-old (AL-32) groups, and from CR-treated (CR) 28-month-old (CR-28) and 32-month-old (CR-32) counterparts to assay the effect of CR on several mitochondrial markers. The age-related decreases in citrate synthase activity, in TFAM, MFN2, and DRP1 protein amounts and in the mtDNA content in the AL-28 group were prevented in CR-28 counterparts. Accordingly, CR reduced oxidative mtDNA damage assessed through the incidence of oxidized purines at specific mtDNA regions in CR-28 animals. These findings support the anti-aging effect of CR up to 28 months. Conversely, the protein amounts of LonP1, Cyt c, OGG1, and APE1 and the 4.8 Kb mtDNA deletion content were not affected in CR-28 rats. The absence of significant differences between the AL-32 values and the CR-32 counterparts suggests an age-related boundary of CR efficacy at this age. However, this only partially curtails the CR benefits in counteracting the generalized aging decline and the related mitochondrial involvement.     

基于C#持久蠕变强度外推功能的实现

持久蠕变强度外推是预测材料在高温高压环境下工作寿命的有效方法。目前常用的外推方法有等温法和参数法。这两种方法都是通过在实验室中采用较短时间的试验，获取试验数据后，通过Excel或者MATLAB等数据处理软件进行数据的拟合处理和外推计算。这些数据归纳统计和数学建模的过程有时需要耗费试验人员的大量精力。介绍了持久蠕变强度外推的软件实现方法，该功能包含在持久蠕变试验设备配备的软件中，试验完成后，软件直接根据试验结果进行数据拟合和持久蠕变强度的外推计算，无需试验数据的统计和建模，大大提高了持久蠕变强度外推计算的效率。     

一种基于实时几何测距的船桥主动防撞方法

本文提出一种基于实时几何测距的船桥主动防撞方法。该方法对船的改动量甚微,仅需维持多项距离矩阵,通过告警逻辑矩阵进行展示与告警,能起到很好的船桥防撞提示效果。     

Controlled synthesis of Ag2O/g-C3N4 heterostructures using soft and hard templates for efficient and enhanced visible-light degradation of ciprofloxacin

Pluronic 31R1 surfactant and MCM-41 silica were used to fabricate mesoporous Ag₂O/g-C₃N₄ heterostructures with improved surface areas. The fabricated mesoporous nanocomposite was used to photo oxidize ciprofloxacin. The TEM images of Ag₂O/g-C₃N₄ indicated a uniform dispersion of spherical approximately 4-nm Ag₂O nanoparticles on g-C₃N₄. The mesoporous 0.9% Ag₂O@g-C₃N₄ heterostructure exhibited 100% efficiency in ciprofloxacin oxidation within 60 min when compared with the 25% efficiency in 120 min of pure mesoporous Ag₂O and 10% efficiency in 120 min of pure g-C₃N₄. The highest ciprofloxacin oxidation efficiency achieved was 100%, which was four and ten times better than those of Ag₂O and g-C₃N₄, respectively. This superior performance of the mesoporous Ag₂O/g-C₃N₄ was attributed to the high dispersion of nano-sized mesoporous Ag₂O particles on the g-C₃N₄ surface, narrow bandgap, and significantly high surface areas. The powerful interaction between Ag₂O and g-C₃N₄ ensured robust durability of Ag₂O/g-C₃N₄ heterostructures, which is evident in the fact that five recycling trials of the photocatalyst rendered a minimal loss of efficiency.     

Reconstructed Water Oxidation Electrocatalysts: The Impact of Surface Dynamics on Intrinsic Activities

Electroreduction of small molecules such as H₂O, CO₂, and N₂ for producing clean fuels or valuable chemicals provides a sustainable approach to meet the increasing global energy demands and to alleviate the concern on climate change resulting from fossil fuel consumption. On the path to implement this purpose, however, several scientific hurdles remain, one of which is the low energy efficiency due to the sluggish kinetics of the paired oxygen evolution reaction (OER). In response, it is highly desirable to synthesize high-performance and cost-effective OER electrocatalysts. Recent advances have witnessed surface reconstruction engineering as a salient tool to significantly improve the catalytic performance of OER electrocatalysts. In this review, recent progress on the reconstructed OER electrocatalysts and future opportunities are discussed. A brief introduction of the fundamentals of OER and the experimental approaches for generating and characterizing the reconstructed active sites in OER nanocatalysts are given first, followed by an expanded discussion of recent advances on the reconstructed OER electrocatalysts with improved activities, with a particular emphasis on understanding the correlation between surface dynamics and activities. Finally, a prospect for clean future energy communities harnessing surface reconstruction-promoted electrochemical water oxidation will be provided.     

Nanoraspberry-like palladium/spongy nickel oxide for electrooxidation of five light fuels

The spongy nickel oxide (SNO) was synthesized the solution combustion method. The SNO was selected as a promoter to boost the catalytic activity of nanoraspberry-like palladium (NRPd) toward electrooxidation of five light fuels (LFs): methanol, ethanol, formaldehyde, formic acid, and ethylene glycol. The X-ray powder diffraction, Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy, and field emission scanning electron microscope techniques were used for the materials characterization. In comparison with nonpromoted Pd, the NRPd-SNO electrocatalyst shown an excellent efficiency in parameters like the electrochemical active surface area and anti-CO poisoning behavior. The turnover data and the parameters, including reaction order, activation energy, and the coefficients of electron transfer and diffusion, were evaluated for the each process of LFs electrooxidation. The outcome for NRPd-SNO activity toward LFs electrooxidation was compared to some reported electrodes. The SNO increases the removal of intermediates created in the oxidation of LFs that can poison the surface of palladium catalyst. This is due to the presence of the lattice oxygens in SNO structure and Ni switching between its high and low valances. The compatibility of the adsorption process of LFs on the surface of the NRPd-SNO catalyst with different isotherms was determined by studying the Tafel polarization and calculating the surface coverage.     

Current Status of Angiogenic Cell Therapy and Related Strategies Applied in Critical Limb Ischemia

Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease (PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated to atherosclerosis. Currently, revascularization strategies (bypass grafting, angioplasty) remain the first option for CLI patients, although less than 45% of them are eligible for surgical intervention mainly due to associated comorbidities. Moreover, patients usually require amputation in the short-term. Angiogenic cell therapy has arisen as a promising alternative for these “no-option” patients, with many studies demonstrating the potential of stem cells to enhance revascularization by promoting vessel formation and blood flow recovery in ischemic tissues. Herein, we provide an overview of studies focused on the use of angiogenic cell therapies in CLI in the last years, from approaches testing different cell types in animal/pre-clinical models of CLI, to the clinical trials currently under evaluation. Furthermore, recent alternatives related to stem cell therapies such as the use of secretomes, exosomes, or even microRNA, will be also described.     

给水管道腐蚀原因及防护措施探讨

给水管道在使用过程中很容易受到人为外力、管道材质、地下水、周围空气、土壤等因素的影响而腐蚀,影响了管道的使用质量和寿命,也带来较大的安全隐患。本文主要是从给水管道腐蚀原因出发,并探讨防护措施。     

Notwendigkeit und Vermarktung von Flexibilitätsoptionen im Energiesystem der Zukunft

Demands on production, distribution and consumption of electrical energy change fundamentally with the energy revolution. Energy purchasing costs for inflexible consumers are rising and proceeds of inflexible producers are sinking. Companies are able to reduce costs by marketing operational flexibility options. This article sets out the need of flexibility in the energy system and the new marketing options. Flexibility potentials within infrastructure plants of a chemical park are analyzed, evaluated regarding marketing and activated in the presented research project FlexChemistry.